International Organization of Standardization (ISO)

The International Organization of Standardization (ISO), Technical Committee on Nanotechnologies (TC 229) has published two new standards for the toxicological testing of nanomaterials. They include a compilation and description of toxicological screening methods for manufactured nanomaterials as well as a method to determine the potency of silver nanoparticles in Staphylococcus aureus.


Both standards can be accessed and purchased via the ISO Online Browsing Platform at



ISO/TR 16197:2014. "Nanotechnologies -- Compilation and description of toxicological screening methods for manufactured nanomaterials"

  • ISO/TR16197:2014 provides a compilation and description of in vitro and in vivo methods that can be useful for the toxicological, including ecotoxicological, screening of engineered and manufactured nanomaterials. It is intended that the toxicological screening tests included in this standard can be used for such purposes as early decision-making in research and product development, rapid feedback on potential toxicological/safety concerns, or for the preliminary assessment of manufactured nanomaterials. ISO/TR16197:2014 is divided between screening assays related to humans and screening assays related to the environment. A screening test is a relatively simple, inexpensive test that can be administered easily and provides an indication of potential adverse outcomes and effects on human health or the environment.


ISO/TS 16550:2014 "Nanotechnologies -- Determination of silver nanoparticles potency by release of muramic acid from Staphylococcus aureus".

  • ISO/TS16550:2014 provides a test method for evaluating potency of silver nanoparticles to cell wall degradation of Staphylococcus aureus – a gram positive bacterium frequently found in the human respiratory tract and on the skin - and muramic acid release, as quantified by a gas chromatography-mass spectrometry (GC-MS).



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