In vitro studies of lung cells and in vivo studies of test animals have shown that certain doses of titanium dioxide (TiO2) particles may cause damage to the lung or lung cells.


Within the project NanoCare, in vitro tests were carried out on human lung cells. Only very high doses (50 µg/cm2) of different variants of titanium dioxide were found to have caused losses in vitality. To simulate the formation of dust, the cells were exposed to titanium dioxide particles for two and four hours, respectively, using the Karlsruhe Exposure System. None of the applied concentrations was found to have caused losses in the cell vitality or signs of acute cell cytotoxicity [1].

Moreover, animal experiments conducted within NanoCare revealed that inhaled TiO2 particles that are deposited in the lungs of the subjects may trigger temporary inflammatory reactions [1]. Please see also the sections on "exposure – in vitro" and "exposure - in vivo".


Literature arrow down

  1. NanoCare 2009, Final Scientific Report, ISBN 978-3-89746-108-6. (PDF-Document, 19 MB).


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