Barium sulfate revealed no damaging effects on organisms during animal tests.


Inhalation experiments on rats have shown that barium sulfate is not deposited in the lung but is completely removed again as the respiratory passages of the animals are cleaned. In medicine, this process is referred to as clearance: Mucus, bacteria, and foreign matter are removed from the body or, in this case, from the respiratory tract, to keep the latter free and avoid infections [1,2].

Within the project NanoCare, both intratracheal instillation tests and inhalation experiments were performed on rats. While a particle suspension is instilled into the pharynx in the case of instillation, the rats inhale the particles through the nose over a defined period of time in the case of inhalation. Neither the instilled nor the inhaled barium sulfate particles showed any biological effects in the different organs of the animals examined subsequently [3].


Literature arrow down

  1. Cullen, RT et al. (2000), Inhal Toxicol, 12(12): 1089-1111.
  2. Tran, CL et al. (2000), Inhal Toxicol, 12(12): 1113-1126.
  3. NanoCare 2009, Final Scientific Report, ISBN 978-3-89746-108-6. (PDF-Document, 19 MB)


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