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Term Definition

Short for Registration, Evaluation, Authorization of Chemicals. REACH is the novel EC regulation no. 1907/2006 that has been in force since June 1, 2007. For further information see


is regarded as a technique for predicting endpoint information for one substance (target substance), by using data from the same endpoint from (an)other substance(s), (source substance(s)). Read-across must be, in all cases, justified scientifically and documented thoroughly.

Risk quotient

Is calculated from an estimated exposure (PEC), divided by an estimated effect (PNEC). If a value less than 1, then there is an acceptable risk. In contrast, if the RQ greater than 1, there is an unacceptable level of risk and measures to reduce exposure should be taken.


Short for reactive oxygen species, the organism considering harmful forms of oxygen, which result from oxidative stress.


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